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Partners

- Institute of Plant Sciences Paris-Saclay (IPS2)
- Industrial partner (confidential)

Abstract of the project

In France, the export market of perfumes and fragrances generates 8.3 billion Euros of exceeding currency. However, in France, cultivation of perfume plants declines since several years, because of international competition and lack of innovation. To tackle this problem, the PISTILL project aims to improve the production of fragrance molecules, using a translational research approach for a plant known to generate strategic fragrances. Producers of this crop are concerned by environmental issues which limit the plant productivity such as drought and the low molecule yields. In addition, the global production and the quality of this molecule are not sufficient to meet the industry needs. The objectives of the PISTILL project are to improve the limiting traits by increasing the genetic diversity of the perfume plant and combine “omics” approaches to select improved plants (i.e. plants yielding (/plant or /hectare) more of the target molecules). The PISTILL project is based on a strong partnership between actors of the commodity chain value, including plant geneticists, chemists, growers, the fragrance industry, the perfume plants technical institutes and a competitiveness cluster. One of the project goals will be to set a start-up company to apply the new “omics” approaches to improve perfume and fragrance plants.

Publications:

Camille Chalvin, Stéphanie Drevensek, Michel Dron, Abdelhafid Bendahmane, Adnane Boualem (2020). Genetic control of glandular trichome development. Trends in Plant Science. 25(5):477-487. doi: 10.1016/j.tplants.2019.12.025.

Camille Chalvin, Stéphanie Drevensek, Françoise Gilard, Caroline Mauve, Christel Chollet, Halima Morin, Edith Nicol, Eva Héripré, Lucie Kriegshauser, Bertrand Gakière, Michel Dron, Abdelhafid Bendahmane, Adnane Boualem (2021). Sclareol and linalyl acetate are produced by glandular trichomes through the MEP pathway. Hortic Res 8, 206. doi.org/10.1038/s41438-021-00640-w

Communications in conferences:

Adnane Boualem. Understanding subcellular and spatial metabolic activity to improve the production of specialized metabolites. IPS2-SPS Symposium, Specialized metabolites: from analysis to engineering. July 4-5, 2019. Orsay – France (talk)

Adnane Boualem, Understanding the biosynthetic pathways of specialized metabolites to breed for more scent: the case of clary sage. Le Studium conference. Biological Activities of Essential Oils. May 13-15, 2019. Orleans - France (talk)

Camille Chalvin, Stéphanie Drevensek, Françoise Gilard, Caroline Mauve, Michel Dron, Abdel Bendahmane, Adnane Boualem (2016). Study of sclareol biosynthesis for clary sage metabolic engineering. “Plant omics and Biotechnology for human Health”; Gent – Belgium (poster)

Camille Chalvin, Stéphanie Drevensek, Françoise Gilard, Caroline Mauve, Michel Dron, Abdel Bendahmane, Adnane Boualem (2017). Study of sclareol biosynthesis for clary sage metabolic engineering. Congrès de la Société Française de Spectrométrie de Masse, Paris - France (talk)

Camille Chalvin, Stéphanie Drevensek, Françoise Gilard, Caroline Mauve, Michel Dron, Abdel Bendahmane, Adnane Boualem (2017). Study of sclareol biosynthesis for clary sage metabolic engineering “Natural Products in Health, Agro-Food and Cosmetics"; Lille – France (poster)

Camille Chalvin, Stéphanie Drevensek, Françoise Gilard, Caroline Mauve, Michel Dron, Abdel Bendahmane, Adnane Boualem (2018). Study of sclareol biosynthesis for clary sage metabolic engineering. « Applied Natural Products » joint Symposium ; Palaiseau - France (talk)

Camille Chalvin, Stéphanie Drevensek, Françoise Gilard, Caroline Mauve, Michel Dron, Abdel Bendahmane, Adnane Boualem (2018). Study of sclareol biosynthesis for clary sage metabolic engineering. « Applied Natural Products » joint Symposium; Palaiseau – France (poster)

Camille Chalvin, Stéphanie Drevensek, Françoise Gilard, Caroline Mauve, Edith Nicol, Eva Héripré, Michel Dron, Abdel Bendahmane, Adnane Boualem (2019). Isotope labeling and mass spectrometry imaging to understand sclareol production in clary sage. Plant Metabolic Engineering Gordon Research Seminar; Lucca - Italy (talk)

PhD defense:

“Sclareol biosynthesis in clary sage and its regulation” by Camille Chalvin, 2019.