Jonathan Weitzman

Jonathan Weitzman

Molecular basis of plant epigenetics / Methodologies

Main research interests 

We study how infectious agents develop intricate mechanisms to hijack the genetic and epigenetic machinery of their host cells to change phenotypic states. We investigate how the intracellular parasite Theileria hijacks host signaling pathways to maintain cell transformation. We recently identified epigenetic events in the host cell nucleus that are induced by the intracellular parasite and we also study epigenetic regulators of the parasite genome. The Theileria-infected leukocytes serve as a model to explore the plasticity of cellular phenotypes, the determinants of cell identities and the evolutionary strategies of interacting cellular systems.

Selection of 3 major recent publications

Marsolier J*, Pineau S*, Medjkane S, Perichon M, Yin Q, Flemington E, Weitzman MD, Weitzman JB. OncomiR addiction is generated by a miR-155 feedback loop in Theileria-transformed leukocytes. (2013) PLoS Pathogens 9(4):e1003222. doi: 10.1371/journal.ppat.1003222

Cheeseman K, Weitzman JB. Host-parasite interactions: an intimate epigenetic relationship. (2015) Cell Microbiol. 2015 17:1121-32. doi: 10.1111/cmi.12471

Marsolier J, Perichon M, DeBarry JD, Villoutreix BO, Chluba J, Lopez T, Garrido C, Zhou XZ, Lu KP, Fritsch L, Ait-Si-Ali S, Mhadhbi M, Medjkane S, Weitzman JB. Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation. (2015) Nature 520:378-82

Contact info

UMR 7216 CNRS/University Paris-Diderot
Bâtiment Lamarck
Case 7042
35 rue Hélène Brion
75205 PARIS cedex 13

Tel: (+33) 1 57 27 89 13

Epigenetics and Cell Fate

Modification date : 29 May 2018 | Publication date : 29 May 2018 | Redactor : JW